Ferrihydrite nanoparticles interaction with model lipid membranes

Chilom, Claudia G.; Zorila, Bogdan; Bacalum, Mihaela; Balasoiu, Maria; Yaroslavtsev, Roman; et al. Chemistry And Physics Of Lipids.DOI: 10.1016/j.chemphyslip.2019.104851

In recent years was observed an increased interest towards the use of metal nanoparticles for various biomedical applications, such as therapeutics, delivery systems or imaging. As biological membranes are the first structures with which the nanoparticles interact, it is necessary to understand better the mechanisms governing these interactions. In the present paper we aim to characterize the effect of three different ferrihydrite nanoparticles (simple or doped with cooper or cobalt) on the fluidity of model lipid membranes. First we evaluated the physicochemical properties of the nanoparticles: size and composition. Secondly, their effect on lipid membranes was also evaluated using Laurdan, TMA-DPH and DPH fluorescence. Our results can help better understand the mechanisms involved in nanoparticles and membrane interactions.