Monitoring of breast cancer progression via aptamer-based detection of circulating tumor cells in clinical blood samples
Kolovskaya, Olga S; Zyuzyukina, Alena V; Dassie, Justin P; Zamay, Galina S; Zamay, Tatiana N; Boyakova, Nina V; Khorzhevskii, Vladimir A; Kirichenko, Daria A; Lapin, Ivan N; Shchugoreva, Irina A; et al// Frontiers in molecular biosciences//
https://doi.org/10.3389/fmolb.2023.1184285
Breast cancer (BC) diagnostics lack noninvasive methods and procedures for screening and monitoring disease dynamics. Admitted CellSearch® is used for fluid biopsy and capture of circulating tumor cells of only epithelial origin. Here we describe an RNA aptamer (MDA231) for detecting BC cells in clinical samples, including blood. The MDA231 aptamer was originally selected against triple-negative breast cancer cell line MDA-MB-231 using cell-SELEX.