Investigation of drug release kinetics from biodegradable polyhydroxyalkanoate microparticles

Lipaikin, S.Y., Dorokhin, A.S., Ryltseva, G.A., (...), Volova, T.G., Shishatskaya, E.I.// Reaction Kinetics, Mechanisms and Catalysis//

https://doi.org/10.1007/s11144-025-02852-w

In this work, spray-dried poly(3-hydroxybutyrate-co-3-hydroxyvalerate) microparticles (P(3HB-co-3HV) MPs) containing conventional antibacterial drug rifampicin (RIF), as well as novel cytostatic ozonide (OZ) were obtained and characterized. The effect of drug chemical structure on its encapsulation and release profile, as well as MPs characteristics (mean size, polydispersity index, zeta potential) was investigated. The obtained RIF-MPs and OZ-MPs revealed the mean diameter of 3.14 ± 0.08 μm and 1.94 ± 0.05 μm, respectively, spherical shape, smooth surface and uniform size distribution. The release of RIF and OZ from the P(3HB-co-3HV) microparticulate matrix had a two-stage pattern with the burst effect and followed the Fickian diffusion-controlled mechanism.